This work deeply discusses the application of Marxist theory in the field of ideological and political education, and analyzes it from multiple perspectives. First of all, it expounds the relationship between the basic principles of Marxism and ideological and political education and its guiding role in ideological and political education, and clarifies the core position of the theory of all-round human development in the goal of ideological and political education. Then, it discusses the effective strategies of promoting the value of ideological and political education, innovating the discourse system, applying the view of interest and the view of mass from the perspectives of Marxist human studies, popularization, interest and mass. Through systematic research, this work provides theoretical support and practical guidance for ideological and political education in colleges and universities in the new era, and is of great significance for promoting the innovation and development of ideological and political education.